Compositions and methods for enhancing delivery of...

Details Compositions and methods for enhancing delivery of... Compositions and methods for enhancing delivery of...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2294709

This invention provides methods and compositions for enhancing transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The methods and compositions are useful for introducing agents into individual cells, as well as cells that are present as a tissue or organ.

Cette invention a trait à des procédés et à des compositions permettant d'accroître le transfert d'un agent dans une cellule. Ces agents peuvent contenir des polypeptides, des polynucléotides tels que des gènes et des acides nucléiques anti-sens, et d'autres molécules. Selon certains modes de réalisation, ces agents sont des agents modulants qui peuvent moduler une activité ou une fonction cellulaire lorsqu'ils sont introduits dans la cellule. Ces procédés et ces compositions sont utilisés pour introduire des agents dans des cellules individuelles, ainsi que dans des cellules présentes sous forme de tissus ou d'un organe.

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