Compositions and methods for enhancing nitric oxide delivery

Details Compositions and methods for enhancing nitric oxide delivery Compositions and methods for enhancing nitric oxide delivery

C - Chemistry, Metallurgy

07

C

C07C 203/04 (2006.01) A61K 31/21 (2006.01) A61K 31/325 (2006.01) A61P 21/00 (2006.01) C07C 201/08 (2006.01)

Patent

CA 2611140

The present invention is directed to compounds, combinations, compositions and methods for enhancing nitric oxide (NO) delivery to target sites, and in particular to muscle, both normal and dystrophic. Enhanced NO delivery according to the present invention may be achieved by using a combination of a muscle relaxant and an NO donor compound, or by using a compound of the invention: formula (I) wherein R1 is H, halo, C1-6 alkoxy or C1- 6 alkyl; R2 is H, NO2 or C (O) NH2; R3 is H, NO2 or C (O) NH2; and at least one of R2 and R3 is NO2; or a pharmaceutically acceptable salt of the compound.

La présente invention concerne des composés, des combinaisons, des préparations et des méthodes d'amélioration de la libération d'oxyde nitrique (NO) dans des sites cibles, et en particulier dans un muscle normal ou dystrophique. L'amélioration de la libération de NO selon la présente invention peut être obtenue en employant une combinaison d'un relaxant musculaire et d'un composé donneur de NO, ou en employant un composé selon l'invention: formule (I) où R1 représente H, un atome d'halogène, un groupement alcoxy en C1-C6 ou un groupement alkyle en C1-C6; R2 représente H, NO2 ou C(O)NH2; R3 représente H, NO2 ou C(O)NH2; et au moins l'un des groupements R2 et R3 représente NO2; ou un sel de qualité pharmaceutique du composé.

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