Compositions and methods for enhancing tolerance for the...

C - Chemistry – Metallurgy – 12 – P

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C12P 7/44 (2006.01) C12N 1/00 (2006.01) C12N 1/20 (2006.01) C12N 15/63 (2006.01) C12N 9/00 (2006.01)

Patent

CA 2675026

Embodiments herein generally relate to methods, compositions and uses for enhancing tolerance of production of organic acids and alcohols by microorganisms. This application also relates generally to methods, compositions and uses of vectors having one or more genetic element to increase the tolerance of organic acids or alcohols by a microorganism. Certain embodiments relate to compositions and methods of enhancing the tolerance for production of 3-hydroxypropionic acid (3-HP) by bacteria. In some embodiments, compositions and methods relate to regulating the expression of an inhibitory molecule of an enhancing gene to increase production of organic acid by bacteria.

Les modes de réalisation de cette invention concernent généralement des procédés, des compositions et des utilisations destinées à améliorer la tolérance de production d'acides organiques et d'alcools à partir de microorganismes. Cette invention concerne également des procédés, des compositions et des utilisations de vecteurs possédant un ou plusieurs éléments génétiques destinés à augmenter la tolérance d'acides organiques ou d'alcools au moyen d'un microorganisme. Certains modes de réalisation concernent des compositions et des procédés destinés à améliorer la tolérance de production d'acide 3-hydroxypropionique (3-HP) à partir de bactéries. D'autres modes de réalisation concernent des compositions et des procédés destinés à réguler l'expression d'une molécule inhibitrice d'un gène améliorant afin d'augmenter la production d'acide organique à partir de bactéries.

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