C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A01K 67/00 (2006.01) A61K 38/00 (2006.01) A61K 38/43 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C12N 1/20 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12N 15/54 (2006.01) C12P 21/06 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2369996
Specific inhibition of EF-2 kinase results in the significant extension of life span without any adverse effects on behavior, development, and reproduction. Moreover, inhibition of this enzyme decreases the rate of aging and results in a more than two-fold increase in the sexually-active period of the life span. Inhibition of the activity of the enzyme results in increased overall protein turnover, which is positively correlated with the decrease in rate of aging and increase in life span.
L'inhibition spécifique de la EF-2 kinase produit un allongement significatif de la durée de vie sans effets indésirables sur le comportement, le développement, et la reproduction. En outre, l'inhibition de cet enzyme ralentit le vieillissement, et multiplie au moins par deux la période d'activité sexuelle. L'inhibition de l'activité de l'enzyme allonge le cycle de reconstitution protonique global, ce qui est corrélé positivement par le ralentissement du vieillissement et l'allongement de la durée de vie.
Driscoll Monica
Nefsky Bradley
Pavur Karen
Ryazanov Alexey G.
Tavernarakis Kektarios
Driscoll Monica
Nefsky Bradley
Pavur Karen
Ryazanov Alexey G.
Smart & Biggar
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