C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 35/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2322659
This invention provides a polynucleotide encoding an antigen that is processed and presented with an MHC Class I molecule on an antigen-presenting cell (APC) and an antigen that is processed and presented with an MHC Class II molecule on the APC. Compositions containing these polynucleotides are further provided by this invention. Methods of increasing presentation of a peptide on the surface of an APC, and APCs produced by the methods, are further provided. Also provided are diagnostic and immunomodulatory methods using polynucleotides, APCs, and immune effector cells of the invention.
L'invention concerne un polynucléotide codant pour un antigène traité et présenté avec une molécule MHC de la classe I sur une cellule présentatrice de l'antigène (CPA), ce polynucléotide codant également pour un antigène traité et présenté avec une molécule MHC de la classe II sur cette cellule CPA. L'invention concerne également des compositions renfermant ces polynucléotides, des méthodes destinées à augmenter la présentation d'un peptide sur la surface d'une cellule CPA, et des cellules CPA produites selon ces méthodes. L'invention concerne enfin des méthodes diagnostiques et immunorégulatrices utilisant les polynucléotides et cellules CPA susmentionnés, ainsi que des cellules immunitaires effectrices.
Genzyme Corporation
Gowling Lafleur Henderson Llp
LandOfFree
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