C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C12N 15/79 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01)
Patent
CA 2760534
An alphavirus vector construct, comprising (a) a 5' promoter which initiates synthesis of viral RNA in vitro from cDNA, (b) a 5' sequence which initiates transcription of alphavirus RNA, (c) a nucleic acid molecule which operably encodes all four alphaviral nonstructural proteins, (d) an alphavirus RNA polymerase recognition sequence; and (e) a 3' polyadenylate tract, wherein said nucleic acid sequence which operably encodes all four alphavirual nonstructural proteins contains a mutation in at least one nonstructural protein in nsP1 residues 346, 441, 473, nsP2 residues 438, 622, 634, 715, nsP3 residues 417, 456, 505, or nsP4 residue 266, as compared to wild-type.
Barnett Susan
Driver David A.
Dubensky Thomas W. Jr.
Frolov Ilya
Gardner Jason P.
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics Inc.
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