C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/79 (2006.01) C12N 15/85 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2463310
Compositions and methods for the high-level, large-scale production of recombinant proteins are disclosed. Illustrative compositions comprise one or more expression vectors capable of high-level protein and/or polypeptide expression in combination with an immortalized host cell-line capable of growth in serum-free, suspension culture. Bi-directional UCOE vectors that permit the simultaneous, high-level expression of two or more recombinant proteins and/or polypeptides from a single UCOE based plasmid vector.
Compositions et procédés pour la production à grande échelle et haut rendement de protéines recombinées. Les compositions décrites contiennent un ou plusieurs vecteurs d'expression capables d'exprimer à haut rendement des protéines et/ou des polypeptides en combinaison avec une lignée cellulaire hôte immortalisée pouvant croître dans une culture en suspension sans sérum. L'invention concerne aussi des vecteurs bidirectionnels UCOE qui permettent d'exprimer à haut rendement simultanément deux ou davantage de protéines recombinées et/ou de polypeptides à partir d'un seul vecteur plasmidique à base d'UCOE.
Bebbington Christopher Robert
Benton Trish
Crombie Robert
Henning Karla Ann
King David J.
Long And Cameron
Ml Laboratories Plc
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