Compositions and methods for hydroxilating epothilones

Details Compositions and methods for hydroxilating epothilones Compositions and methods for hydroxilating epothilones

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C07D 493/04 (2006.01) C07H 21/04 (2006.01) C07K 14/195 (2006.01) C12N 1/20 (2006.01) C12N 9/02 (2006.01) C12N 15/09 (2006.01) C12N 15/31 (2006.01) C12P 17/18 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2510079

Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

L'invention concerne des séquences d'acides nucléiques isolées et des polypeptides ainsi codés destinés à l'hydroxylase de l'épothilone B, ainsi que des mutants et des variants associés, et une ferrédoxine située en aval du gène de l'hydroxylase de l'épothilone B. Cette invention a également trait à des vecteurs et à des cellules contenant ces vecteurs. De plus, ladite invention a pour objet des méthodes de production de micro-organismes, des méthodes d'utilisation de ces micro-organismes recombinants de manière à produire des épothilones de support d'hydroxyalkyle et un analogue d'épothilone produit au moyen d'un mutant de l'hydroxylase de l'épothilone B.

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