Compositions and methods for hydroxylating epothilones

Details Compositions and methods for hydroxylating epothilones Compositions and methods for hydroxylating epothilones

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C07K 1/107 (2006.01) C07K 14/79 (2006.01) C12N 9/02 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12P 17/16 (2006.01) C12P 17/18 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2471874

Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.

La présente invention concerne des séquences d'acide nucléiques isolées et des polypeptides codés par ces dernières qui produisent de l'épothilone B hydroxylase ainsi que des mutants et des variants de cette dernière et une ferrédoxine située en aval du gène d'épothilone B hydroxylase. Cette invention concerne également des vecteurs et des cellules contenant ces vecteurs; des méthodes de production de micro-organismes de recombinaison, des méthodes d'utilisation de ces micro-organismes de recombinaison pour produire des épothilones porteuses d'un groupe hydroxyalkyle et un analogue d'épothilone produit par un mutant de l'épothilone B hydroxylase.

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