Compositions and methods for identifying and targeting...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 31/7034 (2006.01) A61K 31/7048 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2404432

Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Compounds, compositions and methods of treating patients with metastatic colorectal cancer or stomach or esophageal cancer and for imaging metastatic colorectal cancer or stomach or esophageal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as drugs, gene therapeutics and antisense compounds to metastatic colorectal cancer or stomach or esophageal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.

L'invention concerne des réactifs, des ensembles, et des procédés de criblage et de diagnostic du cancer colorectal métastatique ou du cancer primaire et/ou métastatique de l'estomac ou de l'oesophage. L'invention concerne également des composés, des compositions, et des procédés de traitement de malades atteints du cancer colorectal métastatique ou du cancer de l'estomac ou de l'oesophage, ainsi que des procédés d'imagerie de tumeurs du cancer colorectal métastatique ou de tumeurs de l'estomac ou de l'oesophagein vivo. L'invention concerne également des compositions et des procédés d'administration de composés actifs tels que des médicaments, et des composés de thérapie génétique et antisens à des cellules du cancer colorectal métastatique ou du cancer de l'estomac ou de l'oesophage. L'invention concerne également des compositions et des procédés de vaccins destinés au traitement et à la prévention du cancer colorectal métastatique ou du cancer primaire et/ou métastatique de l'estomac ou de l'oesophage.

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