Compositions and methods for immobilizing nucleic acids to...

Details Compositions and methods for immobilizing nucleic acids to... Compositions and methods for immobilizing nucleic acids to...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) B01J 19/00 (2006.01) B01L 3/02 (2006.01) C07B 61/00 (2006.01) C07F 9/24 (2006.01) C12Q 1/68 (2006.01) G01N 35/00 (2006.01) G01N 35/10 (2006.01)

Patent

CA 2267070

Compositions containing at least one bead conjugated to a solid support and further conjugated to at least one macromolecule, such as a nucleic acid and methods for making the compositions are provided. The resulting surfaces formed from the beads linked to the solid support advantageously provide increased surface area for immobilization of biological particles or macromolecules, particularly nucleic acids compared to "flat" surfaces. Furthermore, by selecting a bead with the desired functionality, an appropriate functionalization chemistry for immobilizing the selected macromolecule or biological support, which is different from the chemistry of the solid support, can be produced.

L'invention concerne des compositions qui comprennent au moins une perle d'abord conjuguée à un support solide puis à au moins une macromolécule, tel qu'un acide nucléique, et des procédés de fabrication desdites compositions. Les surfaces résultantes formées à partir des perles liées au support solide produisent une surface accrue pour l'immobilisation de macromolécules ou de particules biologiques, en particulier des acides nucléiques, par rapport aux surfaces "plates". De plus, en sélectionnant une perle présentant la fonctionnalité voulue, on peut produire une substance chimique de fonctionnalisation appropriée pour l'immobilisation de la macromolécule sélectionnée ou le support biologique, qui est différente de celle du support solide.

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