C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/10 (2006.01) A61K 39/116 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 17/00 (2006.01)
Patent
CA 2668100
Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis,Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.
La présente invention concerne les compositions, les dispositifs et procédés, y compris les antigènes immunodominants de pathogènes humains spécifiques (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, le virus de l'Herpes humain 1 et 2, Mycobacterium tuberculosis, Plasmodium falciparum, et le virus Vaccinia) pouvant être utilisés comme vaccin, marqueurs de diagnostic et agents thérapeutiques. En particulier, les antigènes ont des réactivités relatives quantifiées et connues pour les sérums d'une population infectée avec le pathogène, et ont une association connue avec un paramètre de la maladie.
Davies David Huw
Felgner Philip
Liang Xiaowu
Finlayson & Singlehurst
Immport Therapeutics Inc.
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