Compositions and methods for immunomodulation in an organism

Details Compositions and methods for immunomodulation in an organism Compositions and methods for immunomodulation in an organism

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 16/00 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2608474

The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example IL- 15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12)or combinations of both, and an interleukin receptor polypeptide portion, for example IL- 15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, SCID, AIDS, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or Lupus. The therapeutic complex of the invention surprisingly demonstrates increased half-life, and efficacy in vivo.

L'invention concerne un polypeptide thérapeutique ainsi que des méthodes de fabrication et d'utilisation associées permettant de moduler une réponse immunitaire dans un organisme hôte nécessitant une telle réponse. L'invention concerne en particulier l'administration à un organisme d'une quantité efficace d'un complexe polypeptidique précouplé comprenant une partie polypeptidique de lymphokine, par exemple IL- 15 (SEQ ID NO: 5, 6), IL-2 (SEQ ID NO: 10, 12) ou des combinaisons des deux, et une partie polypeptidique de récepteur interleukine, par exemple IL- 15Ra (SEQ ID NO: 7, 8), IL-2Ra (SEQ ID NO: 9, 11) ou des combinaisons des deux, pour renforcer le système immunitaire dans le cas, par exemple, du cancer, de l'immunodéficience combinée grave, du sida ou d'une vaccination; ou pour inhiber le système immunitaire dans le cas, par exemple, de la polyarthrite rhumatoïde ou du lupus. Le complexe thérapeutique selon l'invention présente une demi-vie accrue et une efficacité in vivo.

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