Compositions and methods for immunotherapy of cancer and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/455 (2006.01) A61K 39/012 (2006.01)

Patent

CA 2532250

The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomlexa-related proteins (ARPs) that have immune stimulatory activity and thus have uses in the treatment and prevention of cancer and infectious diseases and in immune modulation. Compositions comprising an ARP are provided. Methods of use of an ARP for the prevention and/or treatment of cancer and/or infectious diseases, for use as an alternative to interleukin-12 (IL-12) treatment, and for eliciting an immune response in a subject, are also provided.

L'invention concerne des composition et des méthodes de prévention et de traitement des maladies néoplasiques primaires et métastatiques et des maladie infectieuses. Ces compositions et méthodes visent à stimuler une réponse immunitaire chez un sujet, et peuvent être utilisées comme solution de rechange au traitement par l'interleukine 12 (IL-12). L'invention concerne en particulier des protéines associées aux Apicomplexa (ARP) présentant une activité de stimulation immunitaire, et pouvant être utilisées dans le traitement et la prévention du cancer et des maladies infectieuses, et dans la modulation immunitaire. L'invention concerne également des compositions contenant une protéine ARP. L'invention concerne encore des méthodes d'utilisation de cette protéine dans la prévention et/ou le traitement du cancer et/ou des maladies infectieuses, comme solution de rechange au traitement par l'interleukine 12 (IL-12), et pour provoquer une réponse immunitaire chez un sujet.

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