A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/4418 (2006.01) A61K 47/00 (2006.01)
Patent
CA 2365536
The present invention relates to triglyceride-free pharmaceutical compositions for delivery of hydrophobic therapeutic agents. Compositions of the present invention include a hydrophobic therapeutic agent and a carrier, where the carrier is formed from a combination of a hydrophilic surfactant and a hydrophobic surfactant. Upon dilution with an aqueous solvent, the composition forms a clear, aqueous dispersion of the surfactants containing the therapeutic agent. The invention also provides methods of treatment with hydrophobic therapeutic agents using these compositions.
L'invention concerne des compositions pharmaceutiques exemptes de triglycérides permettant l'administration d'agents thérapeutiques hydrophobes. Les compositions de l'invention comprennent un agent thérapeutique et un véhicule formé d'une combinaison d'un surfactant hydrophile et d'un surfactant hydrophobe. Lorsqu'elle est diluée dans un solvant aqueux, la composition forme une dispersion aqueuse transparente de surfactants contenant l'agent thérapeutique. L'invention porte également sur des méthodes de traitement à l'aide d'agents thérapeutiques hydrophobes, dans lesquels lesdites compositions sont utilisées.
Chen Feng-Jing
Patel Mahesh V.
Battison Williams Dupuis
Lipocine Inc.
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