Compositions and methods for improved glycoprotein sialylation

Details Compositions and methods for improved glycoprotein sialylation Compositions and methods for improved glycoprotein sialylation

C - Chemistry, Metallurgy

12

N

C12N 15/56 (2006.01) C12N 15/113 (2010.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/24 (2006.01) C12N 15/09 (2006.01) C12P 21/00 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2702120

The present invention provides compositions and methods for the production of glycoproteins with enhanced sialylation. In particular, the invention provides cell lines comprising disrupted sialidase expression and methods of using the cell lines to produce glycoproteins with enhanced sialylation.

La présente invention concerne des compositions et des procédés permettant d'obtenir des glycoprotéines à sialylation améliorée. En particulier, l'invention concerne des lignées cellulaires comprenant une expression interrompue de la sialidase et des procédés d'utilisation desdites lignées cellulaires pour produire des glycoprotéines à sialylation améliorée.

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