Compositions and methods for improving learning and memory

Details Compositions and methods for improving learning and memory Compositions and methods for improving learning and memory

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 49/00 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2373617

Disclosed are methods and an animal model for improving learning or memory in a subject, for treating learning and memory-related degenerative disease in a patient in need of such treatment, for identifying novel agents capable of regulating learning and memory, and for identifying genes involved in biological processes related to learning and memory. The methods and animal model system of the invention utilize the inventor's discovery that improvement of NMDA receptor function, in particular by increased expression of NR2B in the brain, enhances synaptic plasticity and improves learning and memory.

L'invention concerne des procédés et un modèle animal destinés à améliorer l'apprentissage et la mémoire chez un sujet, à traiter des maladies dégénératives liés à l'apprentissage et à la mémoire chez un patient nécessitant un tel traitement, à identifier de nouveaux agents susceptibles de réguler l'apprentissage et la mémoire et à identifier des gènes impliqués dans des processus biologiques relatifs à l'apprentissage et à la mémoire. Les procédés et le système de modèle animal exploitent le fait que l'amélioration de la fonction de récepteur de NMDA, en particulier par une expression accrue de NR2B dans le cerveau, renforce la plasticité synaptique et améliore l'apprentissage et la mémoire.

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