A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/18 (2006.01) A61K 38/21 (2006.01) A61K 38/28 (2006.01) A61K 38/48 (2006.01) A61K 39/145 (2006.01) A61K 47/02 (2006.01)
Patent
CA 2407074
The present invention relates to pharmaceutical compositions and methods to improve expression of exogenous polypeptides into vertebrate cells in vivo, utilizing delivery of polynucleotides encoding such polypeptides. More particularly, the present invention provides the use of salts, in particular sodium and potassium salts of phosphate, in aqueous solution, and auxiliary agents, in particular detergents and surfactants, in pharmaceutical compositions and methods useful for direct polynucleotide-based polypeptide delivery into the cells of vertebrates.
La présente invention se rapporte à des compositions pharmaceutiques et à des méthodes permettant d'améliorer l'expression in vivo de polypeptides exogènes dans des cellules de vertébrés, et ce grâce à l'apport de polynucléotides codant pour ces polypeptides. Plus particulièrement, la présente invention se rapporte à l'utilisation dans des compositions pharmaceutiques de sels, notamment de sels de phosphate de sodium et de potassium, en solution aqueuse, et d'agents auxiliaires, notamment des détergents et des tensioactifs, ainsi qu'à des méthodes s'avérant utiles s'agissant d'administrer à des cellules de vertébrés des polypeptides dérivés de polynucléotides.
Hartikka Jukka
Manthorpe Marston
Sukhu Loretta
Mbm & Co.
Vical Incorporated
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