C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A61K 31/7088 (2006.01) C12N 15/12 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2632794
Methods and cell lines for overexpressing functional gamma-carboxylated proteins are disclosed by way of genetically engineered cell lines which over- express VKORCl. Also disclosed is the antisense inhibition of expression of calumenin in conjunction with overexpression of VKORCl which also increases expression of functional gamma- carboxylated proteins. Gamma-carboxylated proteins of interest may include blood coagulation factors such as human clotting factors IX and VII.
Procédés et lignées cellulaires permettant d'assurer la surexpression de protéines gamma-carboxylées fonctionnelles.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Wake Forest University Health Sciences
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