Compositions and methods for increasing serum antioxidant...

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A23L 1/30 (2006.01) A61K 33/30 (2006.01) A61K 38/38 (2006.01) A61K 38/40 (2006.01) A61P 29/00 (2006.01) A61P 39/06 (2006.01)

Patent

CA 2731463

Compositions and methods are provided for increasing serum antioxidant levels, decreasing serum levels of oxida-tive chemical species, inhibiting insulin-receptor signaling activity, decreasing triglycerides levels, increasing serum ghrelin lev-els, and decreasing serum TNF-alpha levels. Compositions provided comprise a mixture of zinc- charged, fragmented proteins de-rived, for example, from serum or milk. Compositions are administered in a therapeutically effective amount to, for example, re-duce oxidative stress levels in a mammalian subject.

L'invention porte sur des compositions et des procédés pour augmenter les taux d'antioxydant dans le sérum, diminuer les taux dans le sérum d'espèces chimiques oxydantes, inhiber l'activité de signalisation des récepteurs de l'insuline, diminuer les taux de triglycérides, augmenter les taux de ghréline dans le sérum et diminuer les taux de TNF-alpha dans le sérum. Les compositions fournies comprennent un mélange de protéines fragmentées, chargées en zinc, issues par exemple du sérum ou du lait. Les compositions sont administrées dans une quantité thérapeutiquement efficace par exemple pour réduire les taux de stress oxydant dans un sujet mammifère.

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