Compositions and methods for increasing telomerase activity

Details Compositions and methods for increasing telomerase activity Compositions and methods for increasing telomerase activity

C - Chemistry, Metallurgy

07

J

C07J 17/00 (2006.01) A61K 31/58 (2006.01) A61K 31/7048 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2528483

The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.

La présente invention concerne des méthodes et des compositions destinées à augmenter l'activité de la télomérase dans des cellules. Ces compositions contiennent des produits pharmaceutiques, dont des produits topiques et des formulations nutraceutiques. Les méthodes et compositions de l'invention sont utiles pour soigner des maladies pouvant être traitées par une activité accrue de la télomérase dans des cellules ou des tissus d'un patient, tels que, par exemple, l'infection à VIH, diverses maladies dégénératives, ou des dermatoses aiguës ou chroniques. Elles sont également utiles pour améliorer la capacité de réplication de cellules en culture, notamment en matière de thérapie cellulaire ex vivo ou de prolifération de cellules souches.

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