A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2172436
The present invention is directed to a method of inhibiting tumor cell growth. Tumor cells from a patient are transfected to express both B7 and a CD2 ligand on the surface of the transfected tumor cells and these cells are then readministered to the patient. The presence of the B7 and CD2 ligand molecules on the tumor cell surface stimulates a broad immunologic response against both the transfected and non- transfected tumor cells and results in the immunologic killing of localized and metastatic tumor cells. B7 and CD2 ligand transfected tumor cells, or cell membranes, serve as an immune enhancer to engender a potent immunologic response against the surface antigens present on the tumors cells.
Chen Lieping
Hellstrom Karl Erik
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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