Compositions and methods for increasing vascularization

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2685686

Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.

La présente invention concerne des procédés d'augmentation de la vascularisation dans un tissu par l'administration d'un polypeptide de neuroblastine chez un mammifère avec un débit sanguin altéré ou inadéquat dans un tissu. Les procédés peuvent être utilisés dans le traitement ou la prévention d'un trouble caractérisé par un débit sanguin altéré ou inadéquat ou pour augmenter la vascularisation dans un organe qui a été greffé chez un sujet.

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