Compositions and methods for inducing activation of...

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 39/39 (2006.01) A61K 45/06 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2407700

Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particularly, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.

L'invention concerne des compositions permettant d'induire l'activation de cellules dendritiques. Ces compositions comprennent un polynucléotide, tel que des virus, ARN, ADN, ADN plasmidique ou des dérivés de ceci et au moins un copolymère séquencé d'alkyléthers. La présente invention concerne en outre des compositions permettant d'induire l'activation de cellules dendritiques, les copolymères séquencés étant PLURONIC F127 et L61. Plus précisément, les compositions renferment des copolymères séquencés PLURONIC F127/PLURONIC L61. L'invention concerne également des méthodes permettant d'induire l'activation de cellules dendritiques chez des animaux, lesquelles consistent à administrer les compositions selon l'invention. De plus, la présente invention concerne des méthodes permettant d'accroître la réponse immunitaire des animaux, lesquelles consistent à administrer les compositions selon la présente invention.

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