Compositions and methods for inducing gene expression

Details Compositions and methods for inducing gene expression Compositions and methods for inducing gene expression

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2311643

The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivor proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.

L'invention concerne des molécules d'acide nucléique de recombinaison qui codent une protéine de transactivation chimère comportant un domaine de liaison d'ADN d'une protéine de liaison d'ADN et un domaine de protéine capable d'induire une activation transcriptionnelle. L'invention concerne également des vecteurs viraux et non viraux de recombinaison capables d'infecter et/ou de transfecter et d'assurer l'expression d'une protéine de transactivation chimère biologiquement active dans des cellules mammaliennes. L'invention concerne en outre des lignées cellulaires hôtes et des animaux transgéniques non humains capables d'exprimer ladite protéine. L'invention concerne aussi des compositions et des procédés permettant de traiter ou de prévenir les lésions d'origine ischémique associées aux troubles liés à l'hypoxie.

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