Compositions and methods for inhibiting bone resorption

Details Compositions and methods for inhibiting bone resorption Compositions and methods for inhibiting bone resorption

A - Human Necessities

61

K

A61K 31/663 (2006.01) A61K 31/593 (2006.01) A61P 19/08 (2006.01) G01N 33/15 (2006.01) G01N 33/82 (2006.01)

Patent

CA 2467715

Disclosed are compositions and methods for preventing, inhibiting, reducing and treating conditions and diseases associated with abnormal bone resorption in mammals, including for example osteoporosis. Embodiments of compositions of the invention comprise a pharmaceutically effective amount of alendronate and vitamin D3 suitable for once-weekly dosing. Compositions and methods of the invention provide vitamin D nutrition during bisphosphonate treatment to facilitate normal bone formation and mineralization while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcaemia and osteomalacia. Also disclosed are methods for manufacturing compositions of the present invention, for measuring stability and degradation of those compositions, and for measuring blood plasma levels of vitamin D.

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