A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61K 31/19 (2006.01) A61K 31/335 (2006.01) A61K 31/357 (2006.01) A61K 31/66 (2006.01) A61K 31/663 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2448656
The present invention relates to parenteral compositions and methods for inhibiting bone resorption in a mammal while counteracting potential local irritation at injection sites. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a farnesyl diphosphate synthase inhibiting bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a squalene synthase inhibitor.
La présente invention concerne des compositions parentérales et des méthodes pouvant inhiber la résorption osseuse chez un mammifère tout en neutralisant une irritation locale potentielle dans des sites d'injection. Les compositions utiles de l'invention contiennent une combinaison d'une quantité pharmaceutiquement effective d'un bisphosphonate inhibant la farnésyl diphosphate synthase ou un sel pharmaceutiquement acceptable du bisphosphonate, et une quantité pharmaceutiquement effective d'un inhibiteur de la squalène synthase.
Fisher John E.
Reszka Alfred A.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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