A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/66 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/55 (2006.01) C07K 5/00 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01)
Patent
CA 2335471
The present invention relates to oral compositions and methods for inhibiting bone resorption in a mammal while counteracting the occurrence of potentially adverse gastrointestinal effects. The compositions useful herein comprise the combination of a pharmaceutically effective amount of a nitrogen-containing bisphosphonate or a pharmaceutically-acceptable salt thereof and a pharmaceutically effective amount of a caspase inhibitor.
L'invention concerne des compositions orales et des procédés permettant d'inhiber la résorption d'un os chez un mammifère, tout en neutralisant l'apparition d'effets gastro-intestinaux potentiellement contraires. Les compositions utiles sont constituées par la combinaison d'une quantité pharmaceutiquement efficace d'un biphosphonate contenant de l'azote ou d'un sel pharmaceutiquement acceptable de celui-ci et d'une quantité pharmaceutiquement acceptable d'un inhibiteur de captase.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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