Compositions and methods for inhibiting bone resorption

A - Human Necessities – 61 – K

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A61K 31/661 (2006.01) A61K 31/045 (2006.01) A61K 31/075 (2006.01) A61K 31/22 (2006.01) A61K 31/66 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2336201

A new detection scheme for time-of-flight mass spectrometers is disclosed. This detection scheme allows extending the dynamic range of spectrometers operating with a counting technique (TDC). The extended dynamic range is achieved by constructing the multiple anode detector wherein the individual anodes (46 and 47) detect different fractions of the incoming particles (6 and 8). Different anode fractions are achieved by varying the size, physical location, and electrical/magnetic fields of the various anodes. An anode with a small anode fraction avoids saturation and allows an ion detector to render an accurate count of ions even for abundant species.

L'invention concerne un nouveau système de détection applicable aux spectromètres de masse qui mesurent le temps de vol. Le système en question permet d'étendre la gamme dynamique des spectromètres fonctionnant avec une technique de comptage (conversion temporelle-numérique). L'extension de la gamme dynamique résulte de l'élaboration d'un détecteur à anodes multiples dans lequel les anodes individuelles (46, 47) détectent différentes fractions des particules entrantes (6, 8). On obtient ces fractions différentes en faisant varier la taille, l'emplacement physique et les champs électriques/magnétiques des anodes individuelles. Une anode à petite fraction d'anode évite la saturation et permet à un détecteur d'ions de fournir un décompte précis des ions, même pour des espèces abondantes.

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