Compositions and methods for inhibiting cathepsin proteases

Details Compositions and methods for inhibiting cathepsin proteases Compositions and methods for inhibiting cathepsin proteases

C - Chemistry, Metallurgy

07

D

C07D 498/08 (2006.01) A61K 31/395 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2667816

The invention provides compounds (I) and pharmaceutical compositions thereof, and more particularly, bicyclic carbamates, which are useful as cathepsin inhibitors, and methods for using such compounds or pharmaceutically acceptable salts thereof, wherein X is 0 or S; R1 is OR2, halo, (CR2)nR3, nitro, cyano, amino, aniido, sulfonamide, or an optionally substituted C1-6 alkyl, C2-6 alkenyl, or C3-6 alkynyl;R2 is H, (CR2)nR3, or an optionally substituted C1-6alkyl, C2-6 alkenyl or C3-6 alkynyl; R3 is an optionally substituted aryl, heteroaryl, carbocyciic ring or heterocyclic ring; m is 1-3; and n is 0-4.

L'invention concerne des composés (I) et des compositions pharmaceutiques de ceux-ci et plus particulièrement des carbamates bicycliques, lesquels sont utiles en tant qu'inhibiteurs des cathepsines ; et des procédés d'utilisation de tels composés ou de sels acceptables du point de vue pharmaceutique de ceux-ci. [Dans la formule (I), X est O ou S ; R1 est OR2, un halogéno, (CR2)nR3, un nitro, un cyano, un amino, un amido, un sulfonamide ou un alkyle en C1-6, alcényle en C2-6 ou alcynyle en C3-6 éventuellement substitué ; R2 est H, (CR2)nR3 ou un alkyle en C1-6, alcényle en C2-6 ou alcynyle en C3-6 éventuellement substitué ; R3 est un aryle, hétéroaryle, cycle carbocyclique ou hétérocycle éventuellement substitué; m vaut 1-3 ; et n vaut 0-4.]

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