Compositions and methods for inhibiting cellular proliferation

Details Compositions and methods for inhibiting cellular proliferation Compositions and methods for inhibiting cellular proliferation

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 38/57 (2006.01) C07K 14/00 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2280274

Compositions and methods for inhibiting cellular proliferation wherein the composition contains Tissue Factor Pathway Inhibitor (TFPI), a TFPI homolog, or an active fragment thereof. TFPI exhibits potent anti-proliferative activity on human and other animal cells, particularly endothelial cells. More particularly, the TFPI, TFPI homolog, and inhibitory fragment thereof may be combined with a pharmaceutically acceptable excipient or carrier and used to inhibit angiogenesis and angiogenesis-related diseases such as cancer, arthritis, macular degeneration, and diabetic retinopathy.

L'invention concerne des compositions et des procédés destinés à inhiber la prolifération cellulaire, ladite composition renfermant un inhibiteur des voies du facteur III (TFPI) ainsi qu'un homologue du TFPI, ou un fragment actif de ce dernier. Le TFPI présente une forte activité antiproliférante sur les cellules humaines et animales, particulièrement les cellules endothéliales. Le TFPI, l'homologue du TFPI, et le fragment inhibiteur de ce dernier peuvent notamment se combiner à un excipient ou à un support pharmaceutiquement acceptable, et être utilisés pour inhiber l'angiogenèse et des maladies liées à l'angiogenèse, telles que le cancer, l'arthrite, la dégénérescence maculaire, et la rétinopathie diabétique.

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