Compositions and methods for inhibiting cytochrome p450

Details Compositions and methods for inhibiting cytochrome p450 Compositions and methods for inhibiting cytochrome p450

A - Human Necessities

61

K

A61K 31/443 (2006.01) A61K 31/33 (2006.01) A61K 31/343 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/4355 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2665933

Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

La présente invention concerne des procédés destinés à inhiber des enzymes du cytochrome P450 et pouvant être utilisés pour améliorer le traitement de maladies en empêchant la dégradation de médicaments ou d'autres molécules par le cytochrome P450. La présente invention décrit également des compositions pharmaceutiques pouvant agir comme stimulateurs pour améliorer la pharmacocinétique, renforcer la biodisponibilité et l'effet thérapeutique de médicaments qui subissent une dégradation in vivo par des enzymes du cytochrome P450.

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