C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/343 (2006.01) A61K 31/443 (2006.01) A61K 31/495 (2006.01) C07D 307/79 (2006.01)
Patent
CA 2707161
Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 2D6 enzymes.
La présente invention a pour objet des procédés d'inhibition des enzymes du cytochrome P450 2D6 pouvant être utilisés pour l'amélioration du traitement de maladies par la prévention de la dégradation de médicaments ou d'autres molécules par le cytochrome P450 2D6. L'invention concerne des compositions pharmaceutiques qui peuvent agir en tant qu'activateurs pour améliorer la pharmacocinétique, amplifier la biodisponibilité et amplifier l'effet thérapeutique des médicaments qui subissent une dégradation in vivo par les enzymes du cytochrome P450 2D6.
Duan Dehui
Eissenstat Michael
Kang Ji-Hye
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sequoia Pharmaceuticals Inc.
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