Compositions and methods for inhibiting endothelial cell...

Details Compositions and methods for inhibiting endothelial cell... Compositions and methods for inhibiting endothelial cell...

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2394167

Compositions and methods for regulating angiogenic activity wherein the compositions comprise proteins belonging to the family of kringle domain containing proteins and peptides and active fragments thereof are provided. More specifically, compositions and methods comprising kringle domain containing proteins and peptides such as hepatocyte growth factor (HGF) and/or macrophage stimulating protein (MSP), and biologically active fragments thereof are provided. HGF protein fragments of the present invention exhibit potent antiangiogenic activity on human and other animal cells, particularly endothelial cells. More particularly, compositions comprising HGF fragments, and/or HGF fragment homologs, may be combined with a pharmaceutically acceptable excipient or carrier and used to inhibit angiogenesis and angiogenesis-related diseases such as cancer, arthritis, macular degeneration, and diabetic retinopathy.

L'invention concerne des compositions et des procédés de régulation de l'activité angiogénique. Les compositions renferment des protéines de la famille des protéines et des des peptides contenant un domaine Kringle, et des fragments actifs de ces dernières. L'invention concerne plus spécialement des compositions et des procédés renfermant des des protéines et des peptides contenant un domaine Kringle, tels que la protéine du facteur de croissance de l'hépatocyte (HGF) et/ou la protéine de stimulation de macrophages (MSP), et des fragments biologiquement actifs de ces dernières. Les fragments de protéines HGF de la présente invention présentent une activité anti-angiogénique sur des des cellules humaines ou animales, notamment des cellules endothéliales. Plus spécialement, les compositions renfermant des fragments HGF et/ou des homologues des fragments HGF peuvent être combinées à un excipient ou un support pharmaceutiquement acceptable et utilisé afin d'inhiber l'angiogénèse et les maladies liées à l'angiogénèse, telles que le cancer, l'arthrite, la dégénération maculaire et la rétinopathie diabétique.

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