Compositions and methods for inhibiting expression of eg5 gene

Details Compositions and methods for inhibiting expression of eg5 gene Compositions and methods for inhibiting expression of eg5 gene

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2647728

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Eg5 gene (Eg5 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the Eg5 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Eg5 expression and the expression of the Eg5 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Eg5 gene in a cell.

L'invention concerne un acide ribonucléique double brin (ARNdb) destiné à inhiber l'expression du gène Eg5 (gène Eg5) et comprenant un brin antisens renfermant une séquence nucléotidique présentant une longueur inférieure à 30 nucléotides, généralement une longueur comprise entre 19 et 25 nucléotides, cette séquence étant sensiblement complémentaire à une partie au moins du gène Eg5. L'invention concerne également une composition pharmaceutique comprenant cet ARNdb en association avec un support pharmaceutiquement acceptable, des méthodes de traitement de maladies causées par l'expression d'Eg5 et l'expression du gène Eg5 au moyen de cette composition pharmaceutique, ainsi que des méthodes destinées à inhiber l'expression du gène Eg5 dans une cellule.

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