C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01) C12N 9/64 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2743249
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Factor VII gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a Factor VII gene using said pharmaceutical composition; and methods for inhibiting the expression of Factor VII in a cell.
La présente invention concerne un acide ribonucléique double brin (ARNdb) permettant d'inhiber l'expression d'un gène du facteur VII. L'invention concerne également une composition pharmaceutique contenant l'ARNdb ou des molécules ou vecteurs d'acide nucléique codant pour celui-ci ainsi qu'un véhicule pharmaceutiquement acceptable ; des méthodes de traitement de maladies causées par l'expression d'un gène du facteur VII à l'aide de ladite composition pharmaceutique ; et des méthodes d'inhibition de l'expression du facteur VII dans une cellule.
Bramlage Birgit
Constien Rainer
Himber Jacques
Hossbach Markus
Tan Pamela
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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