C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/54 (2006.01)
Patent
CA 2653451
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the IKK-B gene, comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the IKK-B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression or activation of the IKK-B gene using the pharmaceutical composition; and methods for inhibiting the expression of the IKK-B gene in a cell.
L'invention porte sur de l'ARN double brin (dsRNA) inhibant l'expression du gène IKK-B et comprenant un brin antisens dont la séquence nucléotidique, d'une longueur de moins de 30 nucléotides et normalement de 19 à 25 nucléotides, est sensiblement complémentaire d'au moins une partie de celle du gène IKK-B. L'invention porte également un préparation pharmaceutique contenant ledit ARN associé à un vecteur pharmacocompatible, sur des méthodes de traitement de maladies causées par l'expression ou l'activation du gène IKK-B utilisant ladite préparation pharmaceutique, et sur des méthodes d'inhibition de l'expression du gène IKK-B dans une cellule.
Belvisi Maria Gabriela
Birrell Mark Andrew
Catley Matthew Copeland
de Fougerolles Antonin
Harborth Jens
Alnylam Pharmaceuticals Inc.
Imperial Innovations Ltd
Smart & Biggar
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