C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C12N 9/18 (2006.01)
Patent
CA 2750459
This invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a PTP1B gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a PTP1B gene using said pharmaceutical composition; and methods for inhibiting the expression of PTP1B in a cell.
La présente invention concerne un acide ribonucléique à double brin (dsRNA) destiné à inhiber l'expression d'un gène PTPlB. L'invention concerne une composition pharmaceutique comprenant ledit dsRNA ou des molécules d'acide nucléique ou des vecteurs codant pour ceux-ci avec un vecteur pharmaceutiquement acceptable. L'invention porte en outre sur des méthodes de traitement de maladies provoquées par l'expression d'un gène PTPlB, au moyen de ladite composition pharmaceutique. L'invention a également trait à des méthodes d'inhibition de l'expression de PTPlB dans une cellule.
Bramlage Birgit
Constien Rainer
Forst Andrea
Hossbach Markus
Reidhaar-Olson John
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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