Compositions and methods for inhibiting gastric acid secretion

Details Compositions and methods for inhibiting gastric acid secretion Compositions and methods for inhibiting gastric acid secretion

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2607803

The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.

Cette invention concerne des nouvelles compositions orales comprenant un inhibiteur de la pompe à protons H+/K+-ATPase gastrique irréversible (PPI) en tant qu'inhibiteur des sécrétions d'acide gastrique et une ou plusieurs petites molécules d'acides carboxyliques en tant qu'activateurs de cellules pariétales dans la lumière gastrique. De manière inattendue, les compositions décrites dans cette invention peuvent améliorer l'activité antiacide du PPI dans l'estomac. Cette invention concerne également une méthode qui consiste à utiliser ces compositions pour réduire les sécrétions d'acide gastrique chez un mammifère.

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