A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/52 (2006.01) A61K 31/194 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2725437
The present invention is related to novel oral compositions comprising an irreversible gastric H'/K-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti- acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
La présente invention porte sur de nouvelles compositions orales comprenant un inhibiteur de la pompe à protons H+/K+-ATPase (PPI) gastrique irréversible comme inhibiteur de la sécrétion d'acide gastrique et une ou plusieurs petites molécules d'acide carboxylique comme activateurs des cellules pariétales dans la lumière gastrique. De façon inattendue, les compositions de la présente invention sont aptes à augmenter l'activité anti-acide d'un PPI dans l'estomac. De plus, la présente invention porte sur un procédé d'utilisation de telles compositions pour réduire la sécrétion d'acide gastrique chez les mammifères.
Atarot Tal
Kostadinov Aleksey
Naveh Michael
Ridout & Maybee Llp
Vecta Ltd.
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