C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/445 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2171562
There is provided peptide and mimetic inhibitors for the binding of a circumsporozoite polypeptide to receptors of hepatocytes from malaria-susceptible mammals. Aslo contemplated a method of inhibiting the binding of a malaria sporozoites to hepatocytes susceptible to sporozoite invasion. A peptide of Region II+ of the circumsporozoite protein is also provided, as is a method of targeting the delivery of substances to hepatocytes.
Inhibiteurs peptidiques et mimétiques de la liaison d'un polypeptide de circumsporozoïte à des récepteurs d'hépatocytes de mammifères susceptibles de contracter le paludisme. Un procédé permettant d'inhiber la liaison de sporozoïtes du paludisme à des hépatocytes susceptibles d'être envahis par des sporozoïtes est décrit. Un peptide de la région II+ de la protéine de circumsporozoïte est également décrit, ainsi qu'un procédé de ciblage de l'apport desdites substances aux hépatocytes.
Cerami Carla
Frevert Ute
Nussenzweig Victor
Sinnis Photini
Fetherstonhaugh & Co.
New York University
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