Compositions and methods for inhibiting human...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2382030

The present invention relates to nucleic acid molecules involved in HIV infection, proteins encoded by such nucleic acid molecules, and protective compounds including such nucleic acid molecules, proteins and inhibitors of products encoded by such nucleic acid molecules. In addtion, the invention also relates to methods for identifying additional genetic suppressor elements, cellular genes corresponding to such GSEs, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.

L'invention concerne des molécules d'acides nucléiques impliquées dans l'infection au HIV, des protéines codées par de telles molécules, ainsi que des composés protecteurs comprenant ces molécules d'acides nucléiques, ces protéines, et des inhibiteurs de produits codés par lesdites molécules. En outre, l'invention concerne également des procédés d'identification d'éléments suppresseurs génétiques supplémentaires, des gènes cellulaires correspondant à de tels éléments suppresseurs génétiques, ainsi que des procédés d'utilisation de ces gènes cellulaires et des produits de ceux-ci, codés, dans des méthodes de criblage destinées à la sélection d'inhibiteurs supplémentaires du HIV.

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