Compositions and methods for inhibiting pdgfrbeta and vegf-a

Details Compositions and methods for inhibiting pdgfrbeta and vegf-a Compositions and methods for inhibiting pdgfrbeta and vegf-a

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/22 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2716882

Disclosed are antagonists of PDGF recep-tor .beta. (PDGFR.beta.) and VEGF-A, including neutralizing anti-PDGFR.beta. and anti-VEGF-A antibodies, as well as re-lated compositions and methods. Anti-PDGFR.beta. and anti--VEGF-A antibodies disclosed herein include bispecific antibodies capable of binding and neutralizing both PDGFR.beta. and VEGF-A. Also disclosed are methods of treating an neovascular disorder, such as cancer or an neo-vascular ocular disorder, using a PDGFR.beta. and/or VEGF--A antagonist.

La présente invention concerne des antagonistes de récepteur ß de PDGF (PDGFRß) et VEGF-A, comprenant la neutralisation danticorps anti-PDGFRß et anti-VEGF-A, ainsi que des compositions et procédés associés. Les anticorps anti-PDGFRß et anti-VEGF-A présentement décrits comprennent des anticorps bispécifiques capables de se lier à et neutraliser PDGFRß et VEGF-A. Linvention concerne également des procédés de traitement dun trouble néovasculaire, tel que le cancer ou un trouble oculaire néovasculaire, utilisant un antagoniste de PDGFRß et/ou VEGF-A.

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