Compositions and methods for inhibiting the action of androgens

Details Compositions and methods for inhibiting the action of androgens Compositions and methods for inhibiting the action of androgens

A - Human Necessities

61

K

167/191

A61K 31/56 (2006.01)

Patent

CA 1243609

COMPOSITIONS AND METHODS FOR INHIBITING THE ACTION OF ANDROGENS Abstract of the Disclosure Synergistic compositions for inhibiting the ac- tion of androgens comprise the combination in a single topical preparation of a 5 ?-reductase enzyme inhibitor and an androgen receptor blocking agent in a pharmaceutically and dermatologically acceptable vehicle. The compositions may be topically applied to affected areas of the skin in the treatment or prevention of sebaceous gland hypertrophy, hirsutism and male-pattern baldness in mammals. The inhi- bitor and blocking agent are present in the composition in a weight ratio of about 1:20 to 5:1, with the inhibitor comprising up to about 0.1% w/v of the composition and the blocking agent comprising up to about 1% w/v of the compo- sition.

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