A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 31/198 (2006.01) A61K 31/513 (2006.01) A61K 31/7068 (2006.01)
Patent
CA 2706656
The present invention relates to compositions and methods for preventing and treating a condition in a mammalian subject that include at least one inhibitor of double stranded RNA dependent protein kinase (PKR-I) prior to or concurrently with the treatment, wherein the treatment results to an inhibition of activation of dsRNA-dependent protein kinase. The compositions and methods of the present invention further include at least one potentiator that further enhances the inhibition of phosphorylation by PKR-I.
La présente invention concerne des compositions et des procédés pour empêcher et traiter une affection chez un mammifère qui comprennent au moins un inhibiteur de protéine kinase dépendante de l'ARN à double brin (PKR-I) avant ou en même temps que le traitement, le traitement entraînant une inhibition de l'activation de la protéine kinase dépendante de l'ARN à double brin. Les compositions et les procédés de la présente invention comprennent en outre au moins un agent de potentialisation qui améliore en plus l'inhibition de la phosphorylation par PKR-I.
Eley Helen Laura
Miller Kevin Burke
Russell Steve Thomas
Tisdale Michael John
Borden Ladner Gervais Llp
Nestec S.a.
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