Compositions and methods for inhibiting tumor cell growth

Details Compositions and methods for inhibiting tumor cell growth Compositions and methods for inhibiting tumor cell growth

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/45 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2684321

The present invention relates to compositions and methods for inhibiting the activity of an enzyme, for example, Protein Kinase B, p70S6K and/or AbI using the catalytic subunit of Protein Kinase A (PKAc), or at least one PKAc fragment or variant PKAc fragment thereof. In this regard, methods for preventing or treating cancer or a neurodegenerative disease or disorder are also provided.

La présente invention concerne des compositions et des procédés d'inhibition de l'activité d'une enzyme, par exemple, la protéine kinase B, p70S6K et/ou AbI en utilisant une sous-unité catalytique de la protéine kinase A (PKAc), ou au moins un fragment de PKAc ou d'une variante d'un fragment de PKAc de celle-ci. A cet égard, des procédés de prévention ou de traitement du cancer ou d'une maladie ou d'un trouble neurodégénératif sont également proposés.

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