Compositions and methods for inhibiting tumor progression

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/28 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2702462

Compositions and methods are provided for the classification, diagnosis, treatment, and prevention of tumors characterized by loss of REST function, expression of .beta.2, and/or activation of Notch. Further compositions and methods are provided for modulation of cellular processes such as EMT, cell migration, and apoptosis.

La présente invention concerne des compositions et des procédés permettant la classification, le diagnostic, le traitement, et la prévention de tumeurs caractérisée par la perte de la fonction REST (pour RE-1 silencing transcription factor), l'expression de ß2, et/ou l'activation de Notch. L'invention concerne en outre des compositions et des procédés pour la modulation de processus cellulaires tels que la transition épithéliomésenchymateuse (EMT), la migration cellulaire, et l'apoptose.

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