Compositions and methods for inhibiting xenograft rejection

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 35/12 (2006.01) A61K 35/23 (2006.01) A61K 35/407 (2006.01) A61K 35/44 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2221234

The present invention provides compositions and methods useful to inhibit antibody-mediated xenograft rejection by xenogeneic transplant recipients. Accordingly, new methods of transplanting xenografts are also provided. Also provided are compositions which induce antibody-mediated xenograft rejection. Methods for isolating antigen expressed by endothelial cells of a xenograft and which induces antibody-mediated rejection of xenografts are also provided.

Compositions et procédés utiles à l'inhibition du rejet des greffons hétérologues induits par des anticorps chez des receveurs de transplants hétérologues. Sont également décrits de nouveaux procédés de transplantation hétérologue. L'invention concerne également des compositions favorisant le rejet des greffons hétérologues par l'action des anticorps. Des procédés permettant d'isoler des antigènes exprimés par les cellules endothéliales d'un greffon hétérologue, favorisant le rejet des greffons hétérologues induits par les anticorps sont également présentés.

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