Compositions and methods for inhibition of hiv-1 infection

Details Compositions and methods for inhibition of hiv-1 infection Compositions and methods for inhibition of hiv-1 infection

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61K 45/06 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12Q 1/70 (2006.01) G01N 33/542 (2006.01)

Patent

CA 2422275

This invention provides a composition which comprises an admixture of three compounds, wherein: a) one compound is an antibody which binds to a CCR5 receptor; b) one compound retards attachment of HIV-1 to a CD4+ cell by retarding binding of HIV-1 gp120 envelope glycoprotein to CD4 on the surface of the CD4+ cell; and c) one compound retards gp41 from adopting a conformation capable of mediating fusion of HIV-1 to a CD4+ cell by binding noncovalently to an epitope on a gp41 fusion intermediate; wherein the relative mass ratio of any two of the compounds in the admixture ranges form about 100:1 to about 1:100, the composition being effective to inhibit HIV-1 infection of the CD4+ CELL. This invention also provides a method of inhibiting HIV-1 infection of a CD4+ cell which comprises contacting the CD4+ cell with an amount of the composition of the subject invention effective to inhibit HIV-1 infection of the CD4+ cell so as to thereby inhibit HIV-1 infection of the CD4+ cell.

L'invention concerne une composition comprenant un mélange de trois composés : a) un anticorps de liaison à un récepteur CCR5; b) un composé retardant l'attachement du VIH-1 à une cellule CD4+ en retardant la liaison de la glycoprotéine d'enveloppe gp120 du VIH-1 à CD4 sur la surface de la cellule CD4+; et c) un composé retardant l'adoption par gp41 d'une conformation pouvant intervenir dans la fusion du VIH-1 avec une cellule CD4+ par liaison sans covalence à un épitope sur un intermédiaire de fusion gp41, le rapport de masse relatif de deux composés du mélange étant compris entre environ 100:1 et environ 1:100, et la composition servant à inhiber l'infection du VIH-1 de la cellule CD4+. L'invention concerne également un procédé d'inhibition de l'infection du VIH-1 d'une cellule CD4+, consistant à mettre en contact la cellule CD4+ avec une quantité de la composition de la présente invention suffisante pour inhiber l'infection du VIH-1 de la cellule CD4+, afin d'inhiber l'infection du VIH-1 de la cellule CD4+.

Affiliated with

Also associated with

Rating

Compositions and methods for inhibition of hiv-1 infection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for inhibition of hiv-1 infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibition of hiv-1 infection will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1807423