C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/72 (2006.01) A61K 31/195 (2006.01) A61K 31/221 (2006.01) A61K 31/351 (2006.01) C07C 237/22 (2006.01) C07C 271/12 (2006.01) C07D 309/30 (2006.01)
Patent
CA 2477949
Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provided.
Cette invention concerne des inhibiteurs à base de 2-oxo-amide, spécifiques et très puissants, de l'activité de la phospholipase A¿2? (PLA¿2?). Le rôle de l'activité de PLA¿2? étant établi dans les processus inflammatoire à médiation spinale, cette invention concerne une méthodes de traitement de l'hyperalgie et autres états inflammatoires associés à l'activité de PLA¿2.?.
Constantinou-Kokotou Violetta
Dennis Edward
Kokotos George
Lucas Karin Killermann
Six David A.
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
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